منابع مشابه
Molecular signatures of natural selection.
There is an increasing interest in detecting genes, or genomic regions, that have been targeted by natural selection. The interest stems from a basic desire to learn more about evolutionary processes in humans and other organisms, and from the realization that inferences regarding selection may provide important functional information. This review provides a nonmathematical description of the i...
متن کاملIdentification of innate immunity elicitors using molecular signatures of natural selection.
The innate immune system is an ancient and broad-spectrum defense system found in all eukaryotes. The detection of microbial elicitors results in the up-regulation of defense-related genes and the elicitation of inflammatory and apoptotic responses. These innate immune responses are the front-line barrier against disease because they collectively suppress the growth of the vast majority of inva...
متن کاملWidespread Genomic Signatures of Natural Selection in Hominid Evolution
Selection acting on genomic functional elements can be detected by its indirect effects on population diversity at linked neutral sites. To illuminate the selective forces that shaped hominid evolution, we analyzed the genomic distributions of human polymorphisms and sequence differences among five primate species relative to the locations of conserved sequence features. Neutral sequence divers...
متن کاملGenetic signatures of natural selection in a model invasive ascidian
Invasive species represent promising models to study species' responses to rapidly changing environments. Although local adaptation frequently occurs during contemporary range expansion, the associated genetic signatures at both population and genomic levels remain largely unknown. Here, we use genome-wide gene-associated microsatellites to investigate genetic signatures of natural selection in...
متن کاملContext dependence, ancestral misidentification, and spurious signatures of natural selection.
Population genetic analyses often use polymorphism data from one species, and orthologous genomic sequences from closely related outgroup species. These outgroup sequences are frequently used to identify ancestral alleles at segregating sites and to compare the patterns of polymorphism and divergence. Inherent in such studies is the assumption of parsimony, which posits that the ancestral state...
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ژورنال
عنوان ژورنال: Annual Review of Genetics
سال: 2005
ISSN: 0066-4197,1545-2948
DOI: 10.1146/annurev.genet.39.073003.112420